In addition to the treatment of cancer, eNSAIDs would be useful for indications where chronic dosing with NSAIDs is desirable, but currently not feasible such as in the treatment of chronic inflammatory pain (RA, back pain, post-surgical applications), prevention of cancer in high risk populations and treatment and prevention of Alzheimer’s and Parkinson’s Diseases.
Importantly, the ability to administer anti-inflammatory drugs chronically at relatively high doses could enable their use as alternatives to opioids and
help combat the opioid epidemic.
Finally, eNSAIDs have agrochemical applications where nitric oxide and hydrogen sulfide, both powerful plant signaling molecules, prime the organism against abiotic stress such as drought, salinity, and heat.